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KMID : 0352519860230010473
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Korea Univercity Medical Journal
1986 Volume.23 No. 1 p.473 ~ p.485
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Pathological Changes of Middle Ear Mucosa in Experimentally Induced Secretory Otitis Media
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Chu Yeon-Soo
Shin Hong-Soo
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Abstract
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The etiology and pathogenesis of serous otitis media remain a controversal issue, but there is no doubt that Eustachian tube obstruction is an important contributing factor to the development of middle ear effusion.
In an effort to observe the pathological changes of middle ear mucosa during the course of secretory otitis media, study was undertaken correlating the cytological and bacteriological findings with those of ultrastructural pathology in exprimentally induced secretory otitis media of rabbits. The obtained results were as the following;
1. In cytological findings of the effusion comparing the ratio of PMN and lymphocyte, polymorphonuclear leukocyte was dominant for the first 14 days after Eustachian tube obstruction, but lymphocyte was dominant after 14 days. The alteration of the ratio between PMN and lymphocyte follwing the different experimental day after Eustachian tube obstruction was identical with that of cells infilterated in the middle ear mucosa. 2. After 7 days of Eustachian tube obstruction, bacteria were begun to appeared in the middle ear effusion and thereafter the rate of bacterial findings were increased to 750.
- 3. The pathological changes after Eustachian tube obstruction such as epithelial hyperplasia, number of secretory gland and inflammatory reaction were very prominant at the 14 days after Eustachian tube obstruction and then diminished gradually.4. Ciliated cells started to appear in transitional zone of middle ear mucosa after 30 days and were mostly replaced after 60 days of Eustachian tube obstruction. 5. Secretory epithelium were mainly consisted of light granulated cells secreting mucus, these cells appeared in large numbers at the 14 days after Eustachian tube obstruction and then tend to be diminished gradually.
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